In 1974, the National Wildlife Federation funded a field study seeking Bigfoot evidence. No formal federation members were involved and the study made no notable discoveries.

Beginning in the late 1970s, physical anthropologist Grover Krantz published several articles and four book-length treatments of Sasquatch. However, his work was found to contain multiple scientific failings including falling for hoaxes.

A study published in the Journal of Biogeography in 2009 by J.D. Lozier et al. used ecological niche modeling on reported sightings of Bigfoot, using their locations to infer Bigfoot's preferred ecological parameters. They found a very close match with the ecological parameters of the American black bear, Ursus americanus. They also note that an upright bear looks much like Bigfoot's purported appearance and consider it highly improbable that two species should have very similar ecological preferences, concluding that Bigfoot sightings are likely sightings of black bears.

In the first systematic genetic analysis of 30 hair samples that were suspected to be from bigfoot, yeti, sasquatch, almasty or other anomalous primates, only one was found to be primate in origin, and that was identified as human. A joint study by the University of Oxford and Lausanne's Cantonal Museum of Zoology and published in the Proceedings of the Royal Society B in 2014, the team used a previously published cleaning method to remove all surface contamination and the ribosomal mitochondrial DNA 12S fragment of the sample was sequenced and then compared to GenBank to identify the species origin. The samples submitted were from different parts of the world, including the United States, Russia, the Himalayas, and Sumatra. Other than one sample of human origin, all but two are from common animals. Black and brown bear accounted for most of the samples, other animals include cow, horse, dog/wolf/coyote, sheep, goat, raccoon, porcupine, deer and tapir. The last two samples were thought to match a fossilized genetic sample of a 40,000 year old polar bear of the Pleistocene epoch; however, a later study disputes this finding. In the second paper, tests identified the hairs as being from a rare type of brown bear.